Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CETN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CETN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CETN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:152,637,393–152,638,636 | 192.9 kb | Distal (>10kb) Multiome | 264 | |
| chrX:152,821,272–152,821,410 | 9.3 kb | Proximal (<10kb) | 51 | |
| chrX:152,830,434–152,831,338 | 106 bp | At TSS Multiome | 533 | |
| chrX:152,897,448–152,898,309 | 67.2 kb | Distal (>10kb) Multiome | 222 | |
| chrX:152,941,291–152,942,073 | 111.0 kb | Distal (>10kb) Multiome | 549 |
Genomic view of the CETN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.