This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CERT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CERT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CERT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:75,236,392–75,237,296 | 274.7 kb | Distal (>10kb) Multiome | 744 | |
| chr5:75,336,144–75,337,997 | 174.6 kb | Distal (>10kb) Multiome | 912 | |
| chr5:75,465,632–75,466,823 | 45.1 kb | Distal (>10kb) Multiome | 201 | |
| chr5:75,510,698–75,512,248 | 164 bp | At TSS Multiome | 941 | |
| chr5:75,610,714–75,612,105 | 100.1 kb | Distal (>10kb) Multiome | 445 | |
| chr5:75,716,816–75,717,900 | 205.9 kb | Distal (>10kb) Multiome | 836 |
Genomic view of the CERT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.