The protein encoded by this gene was identified as a breast cancer antigen. Nothing more is known of its function at this time. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for CEP85L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP85L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP85L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:117,919,757–117,920,784 | 653.9 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chr6:118,500,134–118,501,000 | 73.6 kb | Distal (>10kb) Multiome | 113 | |
| chr6:118,565,404–118,565,841 | 8.2 kb | Proximal (<10kb) | 117 | |
| chr6:118,580,664–118,581,298 | 6.6 kb | Proximal (<10kb) | 193 | |
| chr6:118,581,825–118,582,441 | 7.8 kb | Proximal (<10kb) | 90 | |
| chr6:118,650,262–118,652,597 | 77.6 kb | Distal (>10kb) Multiome | 979 | |
| chr6:118,709,068–118,709,910 | 135.5 kb | Distal (>10kb) Multiome | 530 | |
| chr6:118,786,272–118,787,718 | 213.0 kb | Distal (>10kb) Multiome | 189 |
Genomic view of the CEP85L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.