The protein encoded by this gene is a centriolar protein involved in primary cilium assembly. Defects in this gene have been associated with infantile nephronophthisis and intellectual disability. [provided by RefSeq, Oct 2016]
Transcription factors with Perturb-seq knockdown data for CEP83. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP83 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP83, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:94,147,883–94,150,737 | 310.8 kb | Distal (>10kb) Multiome HiCAR | 794 | |
| chr12:94,260,806–94,261,454 | 198.7 kb | Distal (>10kb) Multiome | 104 | |
| chr12:94,263,934–94,264,564 | 195.7 kb | Distal (>10kb) Multiome | 188 | |
| chr12:94,389,628–94,390,387 | 70.0 kb | Distal (>10kb) Multiome | 205 | |
| chr12:94,459,523–94,460,634 | 31 bp | At TSS Multiome | 909 | |
| chr12:94,497,980–94,499,094 | 38.8 kb | Distal (>10kb) Multiome | 143 | |
| chr12:94,560,633–94,561,227 | 101.0 kb | Distal (>10kb) Multiome | 348 | |
| chr12:94,590,255–94,590,865 | 130.6 kb | Distal (>10kb) Multiome | 158 | |
| chr12:94,616,266–94,616,971 | 156.7 kb | Distal (>10kb) Multiome | 273 | |
| chr12:94,649,419–94,650,769 | 190.5 kb | Distal (>10kb) Multiome | 452 | |
| chr12:94,731,827–94,732,454 | 272.2 kb | Distal (>10kb) Multiome | 96 |
Genomic view of the CEP83 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.