Enables identical protein binding activity. Predicted to be located in cytoplasm; microtubule; and microtubule organizing center. Predicted to be active in centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CEP57L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP57L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP57L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:108,838,106–108,838,816 | 256.7 kb | Distal (>10kb) Multiome | 212 | |
| chr6:108,847,848–108,848,955 | 246.7 kb | Distal (>10kb) Multiome | 734 | |
| chr6:109,008,977–109,009,970 | 85.6 kb | Distal (>10kb) Multiome | 785 | |
| chr6:109,094,199–109,095,904 | 197 bp | At TSS Multiome | 1009 | |
| chr6:109,186,108–109,187,056 | 91.3 kb | Distal (>10kb) Multiome | 39 | |
| chr6:109,236,275–109,236,762 | 141.5 kb | Distal (>10kb) Multiome | 258 | |
| chr6:109,381,700–109,383,452 | 287.6 kb | Distal (>10kb) Multiome | 1036 |
Genomic view of the CEP57L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.