This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for CEP164. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEP164 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEP164, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:117,097,570–117,099,243 | 229.4 kb | Distal (>10kb) Multiome | 739 | |
| chr11:117,099,458–117,100,103 | 227.9 kb | Distal (>10kb) Multiome | 62 | |
| chr11:117,143,916–117,144,864 | 183.5 kb | Distal (>10kb) Multiome | 969 | |
| chr11:117,178,198–117,179,718 | 149.0 kb | Distal (>10kb) Multiome | 726 | |
| chr11:117,197,957–117,198,434 | 129.8 kb | Distal (>10kb) Multiome | 160 | |
| chr11:117,198,962–117,199,797 | 128.5 kb | Distal (>10kb) Multiome | 211 | |
| chr11:117,231,703–117,233,431 | 95.3 kb | Distal (>10kb) Multiome | 703 | |
| chr11:117,315,726–117,316,638 | 11.6 kb | Distal (>10kb) Multiome | 619 | |
| chr11:117,327,486–117,328,627 | 68 bp | At TSS Multiome | 751 | |
| chr11:117,410,817–117,412,004 | 83.5 kb | Distal (>10kb) Multiome | 247 | |
| chr11:117,429,727–117,430,361 | 102.3 kb | Distal (>10kb) Multiome | 126 | |
| chr11:117,443,412–117,443,876 | 115.9 kb | Distal (>10kb) Multiome | 185 | |
| chr11:117,551,878–117,552,889 | 224.5 kb | Distal (>10kb) Multiome | 100 |
Genomic view of the CEP164 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.