Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CDV3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDV3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDV3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:132,721,513–132,723,554 | 851.0 kb | Distal (>10kb) Multiome HiCAR | 756 | |
| chr3:133,327,859–133,328,993 | 245.1 kb | Distal (>10kb) Multiome | 143 | |
| chr3:133,384,300–133,384,776 | 189.1 kb | Distal (>10kb) Multiome | 247 | |
| chr3:133,661,440–133,662,508 | 88.2 kb | Distal (>10kb) Multiome | 728 | |
| chr3:133,805,616–133,806,520 | 232.2 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the CDV3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.