Transcription factors with Perturb-seq knockdown data for CDRT4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDRT4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDRT4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:15,179,952–15,180,635 | 287.3 kb | Distal (>10kb) Multiome | 149 | |
| chr17:15,260,381–15,261,532 | 206.7 kb | Distal (>10kb) Multiome HiCAR | 596 | |
| chr17:15,341,037–15,342,044 | 126.0 kb | Distal (>10kb) Multiome | 262 | |
| chr17:15,563,178–15,563,830 | 95.9 kb | Distal (>10kb) Multiome | 222 |
Genomic view of the CDRT4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.