This gene product is a member of a large family of CDC2-related serine/threonine protein kinases that accumulates primarily in the nucleus. [provided by RefSeq, Nov 2018]
Transcription factors with Perturb-seq knockdown data for CDKL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDKL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDKL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:50,116,214–50,116,984 | 280.3 kb | Distal (>10kb) Multiome | 818 | |
| chr14:50,231,069–50,232,486 | 165.1 kb | Distal (>10kb) Multiome | 823 | |
| chr14:50,311,389–50,313,095 | 84.6 kb | Distal (>10kb) Multiome | 986 | |
| chr14:50,396,285–50,397,366 | 45 bp | At TSS Multiome | 782 | |
| chr14:50,401,638–50,402,010 | 4.8 kb | Proximal (<10kb) | 87 | |
| chr14:50,531,734–50,533,317 | 135.8 kb | Distal (>10kb) Multiome | 905 | |
| chr14:50,559,970–50,561,283 | 163.7 kb | Distal (>10kb) Multiome | 524 | |
| chr14:50,667,319–50,668,903 | 271.4 kb | Distal (>10kb) Multiome | 914 |
Genomic view of the CDKL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.