Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Involved in positive regulation of myelination. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CDK18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDK18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDK18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:205,210,792–205,212,030 | 293.1 kb | Distal (>10kb) Multiome | 1103 | |
| chr1:205,227,416–205,228,381 | 276.8 kb | Distal (>10kb) Multiome | 495 | |
| chr1:205,229,263–205,229,745 | 275.0 kb | Distal (>10kb) Multiome | 331 | |
| chr1:205,300,603–205,302,127 | 203.1 kb | Distal (>10kb) Multiome | 660 | |
| chr1:205,313,308–205,314,407 | 190.6 kb | Distal (>10kb) Multiome | 327 | |
| chr1:205,321,242–205,322,079 | 182.9 kb | Distal (>10kb) Multiome | 705 | |
| chr1:205,343,395–205,344,420 | 160.7 kb | Distal (>10kb) Multiome HiCAR | 395 | |
| chr1:205,430,507–205,431,109 | 73.8 kb | Distal (>10kb) Multiome | 387 | |
| chr1:205,440,982–205,441,976 | 63.4 kb | Distal (>10kb) Multiome | 341 | |
| chr1:205,444,530–205,445,576 | 59.5 kb | Distal (>10kb) Multiome | 351 | |
| chr1:205,447,468–205,447,874 | 57.2 kb | Distal (>10kb) Multiome | 135 | |
| chr1:205,448,352–205,449,283 | 55.9 kb | Distal (>10kb) Multiome | 269 | |
| chr1:205,449,573–205,450,965 | 54.6 kb | Distal (>10kb) Multiome | 512 | |
| chr1:205,456,289–205,457,681 | 47.4 kb | Distal (>10kb) Multiome | 383 | |
| chr1:205,485,282–205,485,813 | 19.1 kb | Distal (>10kb) Multiome | 590 | |
| chr1:205,502,456–205,503,022 | 2.0 kb | Proximal (<10kb) Multiome | 45 | |
| chr1:205,504,221–205,505,625 | 6 bp | At TSS Multiome | 631 | |
| chr1:205,528,647–205,529,482 | 24.5 kb | Distal (>10kb) Multiome | 390 | |
| chr1:205,543,280–205,544,028 | 39.0 kb | Distal (>10kb) Multiome | 371 | |
| chr1:205,591,729–205,592,393 | 87.4 kb | Distal (>10kb) Multiome | 624 | |
| chr1:205,631,034–205,632,587 | 127.2 kb | Distal (>10kb) Multiome | 1054 | |
| chr1:205,670,539–205,671,380 | 166.2 kb | Distal (>10kb) Multiome | 189 | |
| chr1:205,679,697–205,680,913 | 175.8 kb | Distal (>10kb) Multiome | 568 | |
| chr1:205,706,859–205,707,298 | 202.3 kb | Distal (>10kb) Multiome | 145 | |
| chr1:205,748,908–205,750,848 | 244.9 kb | Distal (>10kb) Multiome | 1074 | |
| chr1:205,774,834–205,775,616 | 270.8 kb | Distal (>10kb) Multiome | 637 |
Genomic view of the CDK18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.