This gene encodes a component of the chromosomal passenger complex. This complex is an essential regulator of mitosis and cell division. This protein is cell-cycle regulated and is required for chromatin-induced microtubule stabilization and spindle formation. Alternate splicing results in multiple transcript variants. Pseudgenes of this gene are found on chromosomes 7, 8 and 16. [provided by RefSeq, Apr 2013]
Transcription factors with Perturb-seq knockdown data for CDCA8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDCA8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDCA8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:37,473,950–37,475,117 | 218.0 kb | Distal (>10kb) Multiome | 695 | |
| chr1:37,513,871–37,515,291 | 177.7 kb | Distal (>10kb) Multiome | 884 | |
| chr1:37,553,845–37,554,497 | 138.2 kb | Distal (>10kb) Multiome | 748 | |
| chr1:37,556,626–37,557,247 | 135.6 kb | Distal (>10kb) Multiome | 284 | |
| chr1:37,595,631–37,596,377 | 96.5 kb | Distal (>10kb) Multiome | 754 | |
| chr1:37,634,598–37,635,064 | 57.7 kb | Distal (>10kb) Multiome | 192 | |
| chr1:37,663,328–37,663,865 | 28.9 kb | Distal (>10kb) Multiome | 44 | |
| chr1:37,690,078–37,690,919 | 2.0 kb | Proximal (<10kb) Multiome | 679 | |
| chr1:37,691,459–37,692,843 | 154 bp | At TSS Multiome | 781 | |
| chr1:37,752,766–37,753,277 | 60.5 kb | Distal (>10kb) Multiome | 223 | |
| chr1:37,793,768–37,794,528 | 101.6 kb | Distal (>10kb) Multiome | 567 | |
| chr1:37,807,583–37,809,057 | 115.7 kb | Distal (>10kb) Multiome | 755 | |
| chr1:37,859,081–37,860,381 | 167.2 kb | Distal (>10kb) Multiome | 939 | |
| chr1:37,931,446–37,932,215 | 239.4 kb | Distal (>10kb) Multiome | 559 | |
| chr1:37,946,605–37,947,220 | 254.5 kb | Distal (>10kb) Multiome | 610 | |
| chr1:37,989,644–37,990,549 | 297.6 kb | Distal (>10kb) Multiome | 1133 |
Genomic view of the CDCA8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.