CDC34
cell division cycle 34, ubiquitin conjugating enzyme | E2-CDC34, UBC3, UBE2R1

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.23
Biological processes 27 terms
DNA replication initiation (GO:0006270)G1/S transition of mitotic cell cycle (GO:0000082)cellular response to interferon-beta (GO:0035458)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)nuclear speck (GO:0016607)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)proteasome-mediated ubiquitin-dependent protein catabolic process (GO:0043161)protein K48-linked ubiquitination (GO:0070936)protein K48-linked ubiquitination (GO:0070936)protein binding (GO:0005515)protein modification process (GO:0036211)protein polyubiquitination (GO:0000209)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)protein ubiquitination (GO:0016567)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin conjugating enzyme activity (GO:0061631)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)
Expression (TPM)
CDC34 — as a Regulated Gene

TFs regulating CDC34 0 TFs

Transcription factors with Perturb-seq knockdown data for CDC34. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC34 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CDC34

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC34, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:289,719–291,481 241.2 kb Distal (>10kb) Multiome 412
chr19:294,836–295,426 236.5 kb Distal (>10kb) Multiome 231
chr19:343,939–345,411 187.0 kb Distal (>10kb) Multiome 600
chr19:408,569–409,459 122.7 kb Distal (>10kb) Multiome 310
chr19:459,789–461,382 71.6 kb Distal (>10kb) Multiome 545
chr19:461,557–462,453 69.7 kb Distal (>10kb) Multiome 580
chr19:488,399–489,918 42.6 kb Distal (>10kb) Multiome 898
chr19:506,451–508,366 24.6 kb Distal (>10kb) Multiome 1001
chr19:510,509–511,797 20.9 kb Distal (>10kb) Multiome 739
chr19:518,865–519,356 12.7 kb Distal (>10kb) Multiome 151
chr19:530,809–533,397 349 bp At TSS Multiome 856
chr19:572,071–573,594 40.7 kb Distal (>10kb) Multiome 888
chr19:588,127–589,976 56.6 kb Distal (>10kb) Multiome 526
chr19:632,653–633,806 101.9 kb Distal (>10kb) Multiome 758
chr19:639,456–640,331 108.0 kb Distal (>10kb) Multiome 389
chr19:662,267–663,864 131.6 kb Distal (>10kb) Multiome 723
chr19:679,616–681,731 149.0 kb Distal (>10kb) Multiome 832
chr19:703,387–704,718 172.3 kb Distal (>10kb) Multiome 586
chr19:708,425–709,293 177.1 kb Distal (>10kb) Multiome 317
chr19:796,668–798,362 265.5 kb Distal (>10kb) Multiome 956
chr19:821,294–822,728 290.4 kb Distal (>10kb) Multiome 254

Genome Browser

Genomic view of the CDC34 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:279,719 – 832,728
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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