The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CDC23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:138,032,174–138,033,856 | 180.2 kb | Distal (>10kb) Multiome | 889 | |
| chr5:138,036,018–138,036,514 | 177.1 kb | Distal (>10kb) Multiome | 359 | |
| chr5:138,095,141–138,095,876 | 117.9 kb | Distal (>10kb) Multiome | 194 | |
| chr5:138,178,349–138,179,428 | 34.4 kb | Distal (>10kb) Multiome | 789 | |
| chr5:138,212,899–138,214,126 | 173 bp | At TSS Multiome | 747 | |
| chr5:138,222,824–138,223,084 | 9.5 kb | Proximal (<10kb) | 316 | |
| chr5:138,241,684–138,242,313 | 28.7 kb | Distal (>10kb) Multiome | 397 | |
| chr5:138,247,699–138,248,212 | 34.6 kb | Distal (>10kb) Multiome | 13 | |
| chr5:138,274,126–138,274,706 | 61.0 kb | Distal (>10kb) Multiome | 161 | |
| chr5:138,331,426–138,332,354 | 118.6 kb | Distal (>10kb) Multiome | 686 | |
| chr5:138,337,358–138,339,397 | 124.8 kb | Distal (>10kb) Multiome | 1134 | |
| chr5:138,352,125–138,353,730 | 139.3 kb | Distal (>10kb) Multiome | 868 | |
| chr5:138,438,317–138,439,353 | 225.6 kb | Distal (>10kb) Multiome | 421 | |
| chr5:138,449,690–138,450,452 | 236.8 kb | Distal (>10kb) Multiome | 486 | |
| chr5:138,463,424–138,467,199 | 251.8 kb | Distal (>10kb) Multiome | 1117 | |
| chr5:138,489,025–138,489,656 | 276.0 kb | Distal (>10kb) Multiome | 185 | |
| chr5:138,491,730–138,492,628 | 278.8 kb | Distal (>10kb) Multiome | 627 |
Genomic view of the CDC23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.