The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for CDC16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CDC16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CDC16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:113,860,084–113,861,280 | 374.3 kb | Distal (>10kb) Multiome HiCAR | 327 | |
| chr13:114,131,895–114,133,058 | 102.3 kb | Distal (>10kb) Multiome | 456 | |
| chr13:114,226,784–114,227,286 | 7.9 kb | Proximal (<10kb) Multiome | 409 | |
| chr13:114,234,692–114,235,425 | 23 bp | At TSS Multiome | 952 | |
| chr13:114,261,338–114,261,888 | 26.7 kb | Distal (>10kb) Multiome | 51 | |
| chr13:114,280,965–114,282,252 | 46.8 kb | Distal (>10kb) Multiome | 896 | |
| chr13:114,314,168–114,314,907 | 79.5 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the CDC16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.