The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Transcription factors with Perturb-seq knockdown data for CD63. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CD63 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CD63, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:55,630,484–55,631,684 | 98.6 kb | Distal (>10kb) Multiome | 41 | |
| chr12:55,645,990–55,646,787 | 83.3 kb | Distal (>10kb) Multiome | 520 | |
| chr12:55,681,171–55,682,136 | 48.0 kb | Distal (>10kb) Multiome | 647 | |
| chr12:55,707,276–55,708,500 | 21.7 kb | Distal (>10kb) Multiome HiCAR | 372 | |
| chr12:55,715,733–55,716,775 | 13.4 kb | Distal (>10kb) Multiome HiCAR | 929 | |
| chr12:55,721,046–55,721,445 | 7.6 kb | Proximal (<10kb) | 305 | |
| chr12:55,724,713–55,724,888 | 4.1 kb | Proximal (<10kb) | 167 | |
| chr12:55,726,828–55,727,197 | 1.8 kb | Proximal (<10kb) | 69 | |
| chr12:55,727,952–55,730,453 | 2 bp | At TSS Multiome | 895 | |
| chr12:55,736,969–55,737,781 | 7.6 kb | Proximal (<10kb) Multiome | 496 | |
| chr12:55,737,830–55,739,085 | 8.9 kb | Proximal (<10kb) Multiome | 475 | |
| chr12:55,742,540–55,744,252 | 13.5 kb | Distal (>10kb) Multiome | 631 | |
| chr12:55,745,091–55,746,361 | 16.2 kb | Distal (>10kb) Multiome | 299 | |
| chr12:55,817,254–55,818,558 | 88.2 kb | Distal (>10kb) Multiome | 749 | |
| chr12:55,829,008–55,831,505 | 100.0 kb | Distal (>10kb) Multiome | 921 | |
| chr12:55,926,651–55,928,471 | 197.3 kb | Distal (>10kb) Multiome | 993 | |
| chr12:55,931,904–55,932,439 | 202.5 kb | Distal (>10kb) Multiome | 279 | |
| chr12:55,940,073–55,940,746 | 210.8 kb | Distal (>10kb) Multiome | 478 | |
| chr12:55,966,006–55,967,470 | 237.1 kb | Distal (>10kb) Multiome | 615 | |
| chr12:55,973,347–55,974,716 | 244.2 kb | Distal (>10kb) Multiome | 966 | |
| chr12:55,996,814–55,997,861 | 267.6 kb | Distal (>10kb) Multiome | 680 | |
| chr12:56,006,888–56,008,461 | 278.0 kb | Distal (>10kb) Multiome | 745 | |
| chr12:56,020,644–56,021,511 | 291.3 kb | Distal (>10kb) Multiome | 364 |
Genomic view of the CD63 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.