Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CCZ1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCZ1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCZ1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:6,526,260–6,527,132 | 299.6 kb | Distal (>10kb) Multiome | 313 | |
| chr7:6,530,620–6,531,774 | 295.1 kb | Distal (>10kb) Multiome | 296 | |
| chr7:6,536,237–6,537,265 | 289.3 kb | Distal (>10kb) Multiome | 223 | |
| chr7:6,577,282–6,577,787 | 248.8 kb | Distal (>10kb) Multiome | 840 | |
| chr7:6,589,551–6,590,781 | 236.2 kb | Distal (>10kb) Multiome | 802 | |
| chr7:6,614,875–6,616,376 | 210.8 kb | Distal (>10kb) Multiome | 610 | |
| chr7:6,640,237–6,641,084 | 185.6 kb | Distal (>10kb) Multiome | 238 | |
| chr7:6,663,809–6,664,686 | 162.2 kb | Distal (>10kb) Multiome | 232 | |
| chr7:6,706,296–6,707,347 | 119.3 kb | Distal (>10kb) Multiome | 718 | |
| chr7:6,729,225–6,730,453 | 96.6 kb | Distal (>10kb) Multiome | 755 | |
| chr7:6,901,511–6,903,145 | 76.1 kb | Distal (>10kb) Multiome | 232 | |
| chr7:6,995,280–6,995,919 | 169.4 kb | Distal (>10kb) Multiome | 100 | |
| chr7:7,099,297–7,099,939 | 273.4 kb | Distal (>10kb) Multiome | 535 | |
| chr7:7,100,140–7,101,112 | 274.4 kb | Distal (>10kb) Multiome | 318 |
Genomic view of the CCZ1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.