Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in vesicle-mediated transport. Located in intracellular membrane-bounded organelle. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CCZ1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCZ1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCZ1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,606,973–5,608,439 | 291.1 kb | Distal (>10kb) Multiome | 322 | |
| chr7:5,781,073–5,781,919 | 117.1 kb | Distal (>10kb) Multiome | 696 | |
| chr7:5,822,727–5,823,386 | 75.6 kb | Distal (>10kb) Multiome | 650 | |
| chr7:5,898,564–5,898,750 | at TSS | At TSS | 106 | |
| chr7:6,008,669–6,009,907 | 110.5 kb | Distal (>10kb) Multiome | 1068 | |
| chr7:6,058,614–6,059,749 | 160.4 kb | Distal (>10kb) Multiome | 916 | |
| chr7:6,081,109–6,081,851 | 182.8 kb | Distal (>10kb) Multiome | 904 | |
| chr7:6,103,982–6,105,662 | 206.1 kb | Distal (>10kb) Multiome | 1040 |
Genomic view of the CCZ1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.