CCT8

chaperonin containing TCP1 subunit 8 | Cctq, PRED71, C21orf112

This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

Member of: DE-1 DE-1.24 Developmental clusters: GC4

Biological processes 36 terms

ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP-dependent protein folding chaperone (GO:0140662)azurophil granule lumen (GO:0035578)cadherin binding (GO:0045296)cell body (GO:0044297)centrosome (GO:0005813)centrosome (GO:0005813)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)extracellular exosome (GO:0070062)extracellular region (GO:0005576)ficolin-1-rich granule lumen (GO:1904813)microtubule (GO:0005874)positive regulation of protein localization to Cajal body (GO:1904871)positive regulation of telomerase RNA localization to Cajal body (GO:1904874)positive regulation of telomere maintenance via telomerase (GO:0032212)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein folding chaperone (GO:0044183)protein stabilization (GO:0050821)secretory granule lumen (GO:0034774)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)zona pellucida receptor complex (GO:0002199)

Expression (TPM)

TFs regulating CCT8 0 TFs

Transcription factors with Perturb-seq knockdown data for CCT8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCT8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CCT8

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCT8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr21:28,884,897–28,885,668	188.4 kb	Distal (>10kb) Multiome	1089
chr21:28,922,250–28,923,423	151.1 kb	Distal (>10kb) Multiome	112
chr21:28,992,126–28,993,365	80.7 kb	Distal (>10kb) Multiome	927
chr21:29,002,426–29,003,155	70.9 kb	Distal (>10kb) Multiome	924
chr21:29,018,921–29,019,505	54.4 kb	Distal (>10kb) Multiome	771
chr21:29,024,275–29,025,379	48.9 kb	Distal (>10kb) Multiome	850
chr21:29,072,977–29,074,186	104 bp	At TSS Multiome	1002
chr21:29,077,172–29,077,673	3.6 kb	Proximal (<10kb)	83
chr21:29,298,181–29,300,594	225.3 kb	Distal (>10kb) Multiome	929

Genome Browser

Genomic view of the CCT8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.