CCT7
chaperonin containing TCP1 subunit 7 | Ccth, Nip7-1

This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]

Member of: DE-1 DE-1.19
Biological processes 32 terms
ATP binding (GO:0005524)ATP hydrolysis activity (GO:0016887)ATP-dependent protein folding chaperone (GO:0140662)cell body (GO:0044297)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)chaperonin-containing T-complex (GO:0005832)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)extracellular exosome (GO:0070062)identical protein binding (GO:0042802)microtubule (GO:0005874)microtubule (GO:0005874)positive regulation of protein localization to Cajal body (GO:1904871)positive regulation of telomerase RNA localization to Cajal body (GO:1904874)positive regulation of telomere maintenance via telomerase (GO:0032212)positive regulation of telomere maintenance via telomerase (GO:0032212)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding chaperone (GO:0044183)protein folding chaperone (GO:0044183)protein stabilization (GO:0050821)protein stabilization (GO:0050821)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)
Expression (TPM)
CCT7 — as a Regulated Gene

TFs regulating CCT7 0 TFs

Transcription factors with Perturb-seq knockdown data for CCT7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCT7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CCT7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCT7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr2:72,951,372–72,951,860 282.8 kb Distal (>10kb) Multiome 115
chr2:72,963,185–72,963,825 270.7 kb Distal (>10kb) Multiome 135
chr2:73,070,503–73,072,300 162.8 kb Distal (>10kb) Multiome 1016
chr2:73,111,353–73,113,710 121.2 kb Distal (>10kb) Multiome 903
chr2:73,156,488–73,157,075 77.5 kb Distal (>10kb) Multiome 419
chr2:73,175,306–73,176,433 58.6 kb Distal (>10kb) Multiome 499
chr2:73,176,845–73,177,711 56.8 kb Distal (>10kb) Multiome 779
chr2:73,202,161–73,203,581 31.8 kb Distal (>10kb) Multiome 227
chr2:73,214,088–73,214,797 19.9 kb Distal (>10kb) Multiome 870
chr2:73,232,770–73,234,882 217 bp At TSS Multiome 1129
chr2:73,268,616–73,269,882 34.9 kb Distal (>10kb) Multiome 384
chr2:73,283,511–73,285,190 50.3 kb Distal (>10kb) Multiome 734
chr2:73,291,197–73,292,186 57.1 kb Distal (>10kb) Multiome 609
chr2:73,293,075–73,294,022 59.4 kb Distal (>10kb) Multiome 382
chr2:73,385,262–73,386,724 151.6 kb Distal (>10kb) Multiome 893

Genome Browser

Genomic view of the CCT7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr2:72,941,372 – 73,396,724
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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