CCNB1IP1

cyclin B1 interacting protein 1 | HEI10, C14orf18

HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.[supplied by OMIM, Apr 2004]

Member of: DE-7 Developmental clusters: GC3

Biological processes 14 terms

chiasma assembly (GO:0051026)chromosome (GO:0005694)condensed nuclear chromosome (GO:0000794)identical protein binding (GO:0042802)nucleus (GO:0005634)protein binding (GO:0005515)protein ubiquitination (GO:0016567)reciprocal meiotic recombination (GO:0007131)reciprocal meiotic recombination (GO:0007131)reciprocal meiotic recombination (GO:0007131)synaptonemal complex (GO:0000795)synaptonemal complex (GO:0000795)synaptonemal complex (GO:0000795)ubiquitin protein ligase activity (GO:0061630)

Expression (TPM)

TFs regulating CCNB1IP1 0 TFs

Transcription factors with Perturb-seq knockdown data for CCNB1IP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCNB1IP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CCNB1IP1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCNB1IP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:20,332,516–20,332,641	670 bp	At TSS	147
chr14:20,332,742–20,333,665	117 bp	At TSS Multiome	694
chr14:20,342,187–20,344,100	10.0 kb	Distal (>10kb) Multiome	1112
chr14:20,412,688–20,413,758	80.0 kb	Distal (>10kb) Multiome	865
chr14:20,454,384–20,455,825	121.8 kb	Distal (>10kb) Multiome	1012
chr14:20,460,777–20,462,259	128.3 kb	Distal (>10kb) Multiome	995
chr14:20,468,846–20,470,856	136.1 kb	Distal (>10kb) Multiome	950
chr14:20,494,584–20,495,486	161.7 kb	Distal (>10kb) Multiome	201
chr14:20,609,147–20,610,547	276.8 kb	Distal (>10kb) Multiome HiCAR	852
chr14:20,612,915–20,614,464	280.4 kb	Distal (>10kb) Multiome	1003
chr14:20,624,684–20,626,122	292.1 kb	Distal (>10kb) Multiome	728
chr14:20,630,325–20,631,286	297.4 kb	Distal (>10kb) Multiome	507
chr14:20,631,700–20,633,862	299.9 kb	Distal (>10kb) Multiome	757

Genome Browser

Genomic view of the CCNB1IP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.