This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for CCL26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCL26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCL26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:75,486,016–75,486,644 | 285.9 kb | Distal (>10kb) Multiome | 434 | |
| chr7:75,527,536–75,528,568 | 244.0 kb | Distal (>10kb) Multiome HiCAR | 667 | |
| chr7:75,531,374–75,531,886 | 240.6 kb | Distal (>10kb) Multiome | 161 | |
| chr7:75,546,305–75,547,063 | 225.6 kb | Distal (>10kb) Multiome | 150 | |
| chr7:75,638,467–75,640,092 | 132.6 kb | Distal (>10kb) Multiome HiCAR | 654 | |
| chr7:75,738,406–75,739,915 | 33.0 kb | Distal (>10kb) Multiome | 795 | |
| chr7:75,762,533–75,762,736 | 9.5 kb | Proximal (<10kb) | 193 | |
| chr7:75,778,655–75,779,512 | 6.9 kb | Proximal (<10kb) Multiome | 54 | |
| chr7:75,779,636–75,779,906 | 7.4 kb | Proximal (<10kb) | 19 | |
| chr7:75,780,667–75,781,151 | 8.6 kb | Proximal (<10kb) Multiome | 106 | |
| chr7:75,781,252–75,782,037 | 9.0 kb | Proximal (<10kb) | 25 | |
| chr7:75,788,149–75,788,821 | 16.2 kb | Distal (>10kb) Multiome | 95 | |
| chr7:75,878,577–75,879,573 | 106.8 kb | Distal (>10kb) Multiome | 883 | |
| chr7:75,914,282–75,915,911 | 142.8 kb | Distal (>10kb) Multiome | 1021 | |
| chr7:75,993,473–75,995,401 | 222.4 kb | Distal (>10kb) Multiome | 873 | |
| chr7:76,047,582–76,048,952 | 275.8 kb | Distal (>10kb) Multiome | 920 |
Genomic view of the CCL26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.