This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for CCKBR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCKBR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCKBR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,234,062–6,235,769 | 25.0 kb | Distal (>10kb) Multiome | 776 | |
| chr11:6,237,822–6,239,512 | 21.0 kb | Distal (>10kb) Multiome | 164 | |
| chr11:6,249,589–6,250,614 | 9.9 kb | Proximal (<10kb) Multiome | 268 | |
| chr11:6,251,174–6,251,654 | 8.5 kb | Proximal (<10kb) Multiome | 193 | |
| chr11:6,258,709–6,260,456 | 146 bp | At TSS Multiome | 283 | |
| chr11:6,266,523–6,266,684 | 6.7 kb | Proximal (<10kb) | 6 | |
| chr11:6,267,833–6,269,111 | 8.6 kb | Proximal (<10kb) Multiome | 142 | |
| chr11:6,280,060–6,282,351 | 21.0 kb | Distal (>10kb) Multiome | 214 | |
| chr11:6,318,947–6,321,304 | 60.2 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,353,367–6,353,932 | 93.7 kb | Distal (>10kb) Multiome | 395 | |
| chr11:6,367,341–6,367,799 | 107.7 kb | Distal (>10kb) Multiome | 55 | |
| chr11:6,389,605–6,390,990 | 130.5 kb | Distal (>10kb) Multiome | 752 | |
| chr11:6,405,086–6,405,670 | 145.6 kb | Distal (>10kb) Multiome | 99 | |
| chr11:6,418,399–6,419,618 | 159.3 kb | Distal (>10kb) Multiome | 494 | |
| chr11:6,468,896–6,469,642 | 209.4 kb | Distal (>10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 214.2 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,480,885–6,482,114 | 221.6 kb | Distal (>10kb) Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 237.4 kb | Distal (>10kb) Multiome | 71 |
Genomic view of the CCKBR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.