This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for CCHCR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCHCR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCHCR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:30,880,638–30,881,295 | 277.2 kb | Distal (>10kb) Multiome | 124 | |
| chr6:30,882,560–30,883,422 | 275.3 kb | Distal (>10kb) Multiome | 308 | |
| chr6:30,883,625–30,885,122 | 273.8 kb | Distal (>10kb) Multiome | 538 | |
| chr6:30,907,770–30,908,494 | 250.1 kb | Distal (>10kb) Multiome | 1005 | |
| chr6:30,913,674–30,914,800 | 244.0 kb | Distal (>10kb) Multiome | 944 | |
| chr6:30,942,475–30,943,087 | 215.3 kb | Distal (>10kb) Multiome | 300 | |
| chr6:30,955,192–30,955,975 | 202.5 kb | Distal (>10kb) Multiome | 524 | |
| chr6:31,157,467–31,159,255 | 205 bp | At TSS Multiome | 740 | |
| chr6:31,159,320–31,159,933 | 1.1 kb | Proximal (<10kb) | 302 | |
| chr6:31,171,796–31,173,419 | 13.9 kb | Distal (>10kb) Multiome | 178 | |
| chr6:31,307,823–31,308,922 | 150.0 kb | Distal (>10kb) Multiome | 248 | |
| chr6:31,366,884–31,367,398 | 208.9 kb | Distal (>10kb) Multiome | 433 | |
| chr6:31,399,631–31,400,231 | 241.7 kb | Distal (>10kb) Multiome | 678 | |
| chr6:31,403,046–31,404,269 | 245.4 kb | Distal (>10kb) Multiome | 796 | |
| chr6:31,441,682–31,442,105 | 283.6 kb | Distal (>10kb) Multiome | 316 |
Genomic view of the CCHCR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.