Enables microtubule binding activity. Involved in several processes, including ciliary transition zone assembly; microtubule cytoskeleton organization; and mitotic metaphase chromosome alignment. Located in several cellular components, including Flemming body; cytoskeleton; and photoreceptor inner segment. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC66. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC66 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC66, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:56,467,084–56,467,577 | 90.0 kb | Distal (>10kb) Multiome | 156 | |
| chr3:56,467,706–56,468,963 | 88.6 kb | Distal (>10kb) Multiome | 376 | |
| chr3:56,556,857–56,557,974 | 8 bp | At TSS Multiome | 756 | |
| chr3:56,682,322–56,683,608 | 126.0 kb | Distal (>10kb) Multiome | 963 | |
| chr3:56,782,366–56,782,841 | 225.5 kb | Distal (>10kb) Multiome | 265 | |
| chr3:56,801,406–56,802,556 | 244.9 kb | Distal (>10kb) Multiome | 717 | |
| chr3:56,823,361–56,824,198 | 266.5 kb | Distal (>10kb) Multiome | 160 |
Genomic view of the CCDC66 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.