Predicted to be involved in cilium movement; outer dynein arm assembly; and spermatid development. Predicted to be active in axoneme. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC63. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC63 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC63, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:110,582,284–110,583,969 | 263.4 kb | Distal (>10kb) Multiome | 740 | |
| chr12:110,613,705–110,614,482 | 232.7 kb | Distal (>10kb) Multiome | 791 | |
| chr12:110,688,496–110,690,180 | 157.5 kb | Distal (>10kb) Multiome | 414 | |
| chr12:110,742,238–110,743,370 | 103.8 kb | Distal (>10kb) Multiome HiCAR | 801 | |
| chr12:110,772,664–110,773,461 | 73.7 kb | Distal (>10kb) Multiome | 88 | |
| chr12:110,846,588–110,847,239 | 115 bp | At TSS Multiome | 371 | |
| chr12:110,860,936–110,861,527 | 14.4 kb | Distal (>10kb) Multiome | 127 | |
| chr12:110,936,931–110,937,646 | 90.5 kb | Distal (>10kb) Multiome | 373 | |
| chr12:111,033,748–111,035,142 | 188.0 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the CCDC63 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.