Enables DNA binding activity. Involved in positive regulation of cell motility. Located in endomembrane system and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:27,490,586–27,491,648 | 281.5 kb | Distal (>10kb) Multiome | 837 | |
| chr8:27,592,228–27,592,758 | 180.2 kb | Distal (>10kb) Multiome | 524 | |
| chr8:27,608,493–27,608,956 | 163.8 kb | Distal (>10kb) Multiome | 168 | |
| chr8:27,614,194–27,615,207 | 157.8 kb | Distal (>10kb) Multiome HiCAR | 844 | |
| chr8:27,633,626–27,634,225 | 138.7 kb | Distal (>10kb) Multiome | 300 | |
| chr8:27,729,944–27,730,631 | 42.3 kb | Distal (>10kb) Multiome | 159 | |
| chr8:27,772,146–27,773,026 | 14 bp | At TSS Multiome | 823 | |
| chr8:27,774,174–27,774,993 | 1.8 kb | Proximal (<10kb) Multiome | 712 | |
| chr8:27,837,400–27,838,016 | 65.2 kb | Distal (>10kb) Multiome | 867 |
Genomic view of the CCDC25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.