Predicted to enable small GTPase binding activity. Predicted to be involved in vesicle cytoskeletal trafficking. Predicted to act upstream of or within insulin secretion involved in cellular response to glucose stimulus and response to bacterium. Predicted to be located in Golgi apparatus. Predicted to be active in trans-Golgi network. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC186. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC186 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC186, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:114,042,897–114,045,651 | 130.5 kb | Distal (>10kb) Multiome | 503 | |
| chr10:114,173,477–114,175,128 | 83 bp | At TSS Multiome | 842 | |
| chr10:114,179,165–114,179,646 | 5.0 kb | Proximal (<10kb) | 116 | |
| chr10:114,239,111–114,240,320 | 65.4 kb | Distal (>10kb) Multiome | 417 | |
| chr10:114,303,821–114,305,401 | 130.7 kb | Distal (>10kb) Multiome | 424 | |
| chr10:114,402,845–114,405,341 | 230.4 kb | Distal (>10kb) Multiome | 410 | |
| chr10:114,441,939–114,442,669 | 268.1 kb | Distal (>10kb) Multiome | 90 | |
| chr10:114,471,249–114,473,211 | 298.3 kb | Distal (>10kb) Multiome | 486 |
Genomic view of the CCDC186 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.