The function of this gene and its encoded protein is not known. Several genome-wide association studies have implicated the region around this gene to be involved in breast cancer and bone mineral density, but no link to this specific gene has been found. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for CCDC170. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC170 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC170, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:151,239,598–151,241,662 | 253.7 kb | Distal (>10kb) Multiome | 604 | |
| chr6:151,389,414–151,392,227 | 103.6 kb | Distal (>10kb) Multiome | 1234 | |
| chr6:151,451,713–151,453,312 | 41.8 kb | Distal (>10kb) Multiome | 1109 | |
| chr6:151,456,653–151,457,328 | 37.0 kb | Distal (>10kb) Multiome | 65 | |
| chr6:151,493,661–151,494,985 | 108 bp | At TSS Multiome | 691 | |
| chr6:151,501,870–151,502,275 | 7.9 kb | Proximal (<10kb) | 78 | |
| chr6:151,589,007–151,590,183 | 95.7 kb | Distal (>10kb) Multiome | 147 | |
| chr6:151,646,686–151,647,288 | 153.0 kb | Distal (>10kb) Multiome | 84 | |
| chr6:151,647,848–151,649,022 | 154.4 kb | Distal (>10kb) Multiome | 205 | |
| chr6:151,683,003–151,684,338 | 189.6 kb | Distal (>10kb) Multiome | 214 | |
| chr6:151,763,286–151,764,765 | 270.2 kb | Distal (>10kb) Multiome | 422 |
Genomic view of the CCDC170 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.