Transcription factors with Perturb-seq knockdown data for CCDC152. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC152 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC152, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:41,868,976–41,871,057 | 886.4 kb | Distal (>10kb) Multiome HiCAR | 726 | |
| chr5:41,924,742–41,926,001 | 831.5 kb | Distal (>10kb) Multiome HiCAR | 1012 | |
| chr5:42,751,103–42,751,346 | 5.5 kb | Proximal (<10kb) | 26 | |
| chr5:42,756,638–42,757,621 | 50 bp | At TSS Multiome | 314 | |
| chr5:42,811,575–42,812,593 | 55.3 kb | Distal (>10kb) Multiome | 702 | |
| chr5:42,813,381–42,813,999 | 56.9 kb | Distal (>10kb) Multiome | 122 | |
| chr5:42,893,601–42,894,516 | 137.2 kb | Distal (>10kb) Multiome | 155 | |
| chr5:42,908,461–42,909,511 | 152.2 kb | Distal (>10kb) Multiome | 451 | |
| chr5:43,016,201–43,016,848 | 259.6 kb | Distal (>10kb) Multiome | 194 | |
| chr5:43,017,299–43,018,875 | 261.2 kb | Distal (>10kb) Multiome | 870 | |
| chr5:43,024,983–43,026,034 | 268.7 kb | Distal (>10kb) Multiome | 130 | |
| chr5:43,041,652–43,043,529 | 285.4 kb | Distal (>10kb) Multiome | 897 |
Genomic view of the CCDC152 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.