Involved in cilium assembly and positive regulation of centriole elongation. Located in centriole and centrosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:124,673,250–124,674,391 | 280.4 kb | Distal (>10kb) Multiome | 715 | |
| chr11:124,739,482–124,740,822 | 214.3 kb | Distal (>10kb) Multiome | 498 | |
| chr11:124,745,504–124,747,699 | 207.3 kb | Distal (>10kb) Multiome | 676 | |
| chr11:124,758,225–124,760,203 | 195.6 kb | Distal (>10kb) Multiome | 594 | |
| chr11:124,799,320–124,800,957 | 153.7 kb | Distal (>10kb) Multiome | 893 | |
| chr11:124,839,093–124,840,110 | 114.4 kb | Distal (>10kb) Multiome | 246 | |
| chr11:124,842,870–124,844,108 | 110.8 kb | Distal (>10kb) Multiome | 219 | |
| chr11:124,875,886–124,877,815 | 77.7 kb | Distal (>10kb) Multiome | 769 | |
| chr11:124,920,725–124,921,671 | 33.0 kb | Distal (>10kb) Multiome | 329 | |
| chr11:124,953,809–124,954,493 | 109 bp | At TSS Multiome | 818 | |
| chr11:125,062,600–125,064,019 | 109.0 kb | Distal (>10kb) Multiome | 640 | |
| chr11:125,111,022–125,112,225 | 157.6 kb | Distal (>10kb) Multiome | 651 | |
| chr11:125,163,468–125,165,998 | 210.5 kb | Distal (>10kb) Multiome | 417 | |
| chr11:125,224,246–125,224,764 | 270.4 kb | Distal (>10kb) Multiome | 63 | |
| chr11:125,239,981–125,240,709 | 286.1 kb | Distal (>10kb) Multiome | 103 | |
| chr11:125,330,306–125,331,087 | 376.6 kb | Distal (>10kb) Multiome HiCAR | 104 | |
| chr11:125,404,667–125,405,169 | 450.8 kb | Distal (>10kb) Multiome HiCAR | 273 | |
| chr11:125,443,557–125,444,361 | 489.8 kb | Distal (>10kb) Multiome HiCAR | 142 |
Genomic view of the CCDC15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.