Transcription factors with Perturb-seq knockdown data for CCDC148. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC148 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC148, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:158,336,936–158,337,781 | 119.4 kb | Distal (>10kb) Multiome | 92 | |
| chr2:158,456,262–158,458,696 | 1.4 kb | Proximal (<10kb) Multiome | 1107 | |
| chr2:158,464,738–158,464,882 | 8.0 kb | Proximal (<10kb) | 63 | |
| chr2:158,744,999–158,745,940 | 288.7 kb | Distal (>10kb) Multiome | 282 |
Genomic view of the CCDC148 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.