Transcription factors with Perturb-seq knockdown data for CCDC144NL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC144NL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC144NL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:20,843,455–20,844,334 | 24.2 kb | Distal (>10kb) Multiome | 77 | |
| chr17:20,868,077–20,868,766 | 230 bp | At TSS Multiome | 123 | |
| chr17:20,908,196–20,908,861 | 40.4 kb | Distal (>10kb) Multiome | 516 | |
| chr17:20,992,594–20,993,594 | 124.9 kb | Distal (>10kb) Multiome | 237 | |
| chr17:21,041,818–21,044,206 | 175.1 kb | Distal (>10kb) Multiome | 1019 | |
| chr17:21,098,970–21,099,982 | 231.1 kb | Distal (>10kb) Multiome | 514 | |
| chr17:21,106,347–21,107,024 | 238.4 kb | Distal (>10kb) Multiome | 32 | |
| chr17:21,108,710–21,109,234 | 240.7 kb | Distal (>10kb) Multiome | 13 | |
| chr17:21,126,572–21,127,535 | 258.8 kb | Distal (>10kb) Multiome | 707 |
Genomic view of the CCDC144NL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.