Predicted to be involved in acrosome assembly and single fertilization. Predicted to be located in cytoplasmic vesicle and membrane. Predicted to be active in acrosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CCDC136. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC136 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC136, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:128,530,813–128,532,054 | 259.5 kb | Distal (>10kb) Multiome | 421 | |
| chr7:128,697,256–128,697,860 | 93.2 kb | Distal (>10kb) Multiome | 373 | |
| chr7:128,738,818–128,739,927 | 51.5 kb | Distal (>10kb) Multiome | 899 | |
| chr7:128,782,847–128,783,828 | 7.3 kb | Proximal (<10kb) Multiome | 559 | |
| chr7:128,790,457–128,792,157 | 585 bp | At TSS Multiome | 579 | |
| chr7:128,831,024–128,832,923 | 41.9 kb | Distal (>10kb) Multiome | 529 | |
| chr7:128,842,024–128,842,470 | 51.5 kb | Distal (>10kb) Multiome | 308 | |
| chr7:128,862,244–128,863,913 | 72.0 kb | Distal (>10kb) Multiome | 736 | |
| chr7:128,868,986–128,870,326 | 78.9 kb | Distal (>10kb) Multiome | 557 | |
| chr7:128,879,898–128,880,508 | 89.4 kb | Distal (>10kb) Multiome HiCAR | 323 | |
| chr7:128,890,731–128,891,934 | 100.6 kb | Distal (>10kb) Multiome | 231 | |
| chr7:128,911,320–128,912,136 | 120.9 kb | Distal (>10kb) Multiome | 216 | |
| chr7:128,937,568–128,938,346 | 147.2 kb | Distal (>10kb) Multiome | 392 | |
| chr7:129,054,212–129,055,537 | 264.3 kb | Distal (>10kb) Multiome | 1049 |
Genomic view of the CCDC136 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.