Enables protein-macromolecule adaptor activity. Involved in positive regulation of signal transduction; regulation of ossification; and regulation of protein glycosylation. Located in cytosol and intracellular membrane-bounded organelle. Is active in endoplasmic reticulum lumen. Implicated in osteogenesis imperfecta. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CCDC134. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CCDC134 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CCDC134, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:41,512,659–41,513,151 | 287.7 kb | Distal (>10kb) Multiome | 354 | |
| chr22:41,543,855–41,544,782 | 256.1 kb | Distal (>10kb) Multiome | 755 | |
| chr22:41,589,188–41,590,530 | 210.7 kb | Distal (>10kb) Multiome | 758 | |
| chr22:41,620,173–41,622,049 | 179.5 kb | Distal (>10kb) Multiome | 880 | |
| chr22:41,666,496–41,667,405 | 133.8 kb | Distal (>10kb) Multiome | 725 | |
| chr22:41,697,169–41,697,792 | 103.3 kb | Distal (>10kb) Multiome | 464 | |
| chr22:41,800,274–41,801,345 | 66 bp | At TSS Multiome | 816 | |
| chr22:41,832,291–41,834,215 | 32.2 kb | Distal (>10kb) Multiome | 1023 | |
| chr22:41,845,927–41,846,489 | 45.5 kb | Distal (>10kb) Multiome | 271 | |
| chr22:41,909,821–41,910,788 | 109.6 kb | Distal (>10kb) Multiome | 251 | |
| chr22:41,913,915–41,914,497 | 113.5 kb | Distal (>10kb) Multiome | 143 | |
| chr22:41,914,624–41,915,454 | 114.4 kb | Distal (>10kb) Multiome | 273 | |
| chr22:41,919,501–41,920,436 | 119.3 kb | Distal (>10kb) Multiome | 337 | |
| chr22:41,926,076–41,926,820 | 125.6 kb | Distal (>10kb) Multiome | 442 | |
| chr22:41,945,821–41,947,304 | 146.3 kb | Distal (>10kb) Multiome | 896 | |
| chr22:41,957,553–41,958,332 | 157.2 kb | Distal (>10kb) Multiome | 456 | |
| chr22:41,976,503–41,977,084 | 176.1 kb | Distal (>10kb) Multiome | 294 | |
| chr22:42,070,303–42,071,253 | 270.2 kb | Distal (>10kb) Multiome | 833 | |
| chr22:42,074,171–42,074,703 | 273.7 kb | Distal (>10kb) Multiome | 178 | |
| chr22:42,079,194–42,080,293 | 279.1 kb | Distal (>10kb) Multiome | 872 | |
| chr22:42,090,032–42,091,609 | 290.2 kb | Distal (>10kb) Multiome | 910 |
Genomic view of the CCDC134 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.