CBLC
Cbl proto-oncogene C | CBL-3, CBL-SL, RNF57

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

Biological processes 23 terms
SH3 domain binding (GO:0017124)calcium ion binding (GO:0005509)cell surface receptor signaling pathway (GO:0007166)epidermal growth factor receptor binding (GO:0005154)membrane raft (GO:0045121)negative regulation of MAPK cascade (GO:0043409)negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)phosphotyrosine residue binding (GO:0001784)phosphotyrosine residue binding (GO:0001784)plasma membrane (GO:0005886)protein binding (GO:0005515)protein catabolic process (GO:0030163)protein ubiquitination (GO:0016567)receptor tyrosine kinase binding (GO:0030971)regulation of signaling (GO:0023051)signal transduction (GO:0007165)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-protein transferase activity (GO:0004842)zinc ion binding (GO:0008270)
Expression (TPM)
CBLC — as a Regulated Gene

TFs regulating CBLC 0 TFs

Transcription factors with Perturb-seq knockdown data for CBLC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CBLC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to CBLC

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CBLC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:44,499,680–44,500,955 277.3 kb Distal (>10kb) Multiome 1007
chr19:44,643,571–44,644,620 134.0 kb Distal (>10kb) Multiome 710
chr19:44,747,085–44,747,789 30.3 kb Distal (>10kb) Multiome 653
chr19:44,757,112–44,758,480 20.5 kb Distal (>10kb) Multiome 209
chr19:44,758,633–44,759,104 19.0 kb Distal (>10kb) Multiome 80
chr19:44,770,589–44,771,108 7.1 kb Proximal (<10kb) Multiome 367
chr19:44,777,671–44,778,314 3 bp At TSS Multiome 353
chr19:44,784,441–44,784,669 6.6 kb Proximal (<10kb) 319
chr19:44,800,231–44,800,829 22.7 kb Distal (>10kb) Multiome 508
chr19:44,807,965–44,809,338 30.2 kb Distal (>10kb) Multiome 652
chr19:44,844,448–44,848,668 66.9 kb Distal (>10kb) Multiome 1047
chr19:44,890,209–44,891,796 113.0 kb Distal (>10kb) Multiome 952
chr19:44,903,686–44,904,241 125.9 kb Distal (>10kb) Multiome 666
chr19:44,905,114–44,907,037 128.8 kb Distal (>10kb) Multiome 645
chr19:44,913,546–44,915,671 137.3 kb Distal (>10kb) Multiome 587
chr19:44,926,693–44,927,388 149.3 kb Distal (>10kb) Multiome 277
chr19:44,954,641–44,955,824 177.4 kb Distal (>10kb) Multiome 835
chr19:45,001,031–45,002,639 223.5 kb Distal (>10kb) Multiome 694
chr19:45,038,879–45,039,566 261.2 kb Distal (>10kb) Multiome 800
chr19:45,075,125–45,076,814 298.6 kb Distal (>10kb) Multiome 710

Genome Browser

Genomic view of the CBLC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:44,489,680 – 45,086,814
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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