The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]
Transcription factors with Perturb-seq knockdown data for CASP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:184,472,503–184,475,460 | 174.7 kb | Distal (>10kb) Multiome | 965 | |
| chr4:184,536,785–184,538,298 | 111.8 kb | Distal (>10kb) Multiome | 704 | |
| chr4:184,625,573–184,626,654 | 23.3 kb | Distal (>10kb) Multiome | 388 | |
| chr4:184,648,062–184,650,476 | 125 bp | At TSS Multiome | 822 | |
| chr4:184,733,143–184,734,876 | 84.8 kb | Distal (>10kb) Multiome | 1145 | |
| chr4:184,814,706–184,816,098 | 165.9 kb | Distal (>10kb) Multiome | 552 | |
| chr4:184,825,249–184,826,846 | 176.6 kb | Distal (>10kb) Multiome | 644 |
Genomic view of the CASP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.