Transcription factors with Perturb-seq knockdown data for CASC15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CASC15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CASC15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:21,386,604–21,387,271 | 278.6 kb | Distal (>10kb) Multiome | 154 | |
| chr6:21,423,028–21,423,960 | 242.0 kb | Distal (>10kb) Multiome | 183 | |
| chr6:21,449,935–21,450,977 | 215.2 kb | Distal (>10kb) Multiome | 209 | |
| chr6:21,539,532–21,540,359 | 125.6 kb | Distal (>10kb) Multiome | 120 | |
| chr6:21,586,889–21,589,570 | 76.3 kb | Distal (>10kb) Multiome | 917 | |
| chr6:21,593,301–21,595,945 | 71.8 kb | Distal (>10kb) Multiome | 834 | |
| chr6:21,609,657–21,610,431 | 55.5 kb | Distal (>10kb) Multiome | 133 | |
| chr6:21,664,041–21,666,739 | 532 bp | At TSS Multiome | 502 | |
| chr6:21,667,044–21,667,745 | 1.5 kb | Proximal (<10kb) | 141 | |
| chr6:21,717,678–21,718,459 | 52.7 kb | Distal (>10kb) Multiome | 133 | |
| chr6:21,722,533–21,723,553 | 57.3 kb | Distal (>10kb) Multiome | 99 | |
| chr6:21,907,989–21,908,936 | 243.0 kb | Distal (>10kb) Multiome | 127 | |
| chr6:21,953,598–21,954,717 | 288.7 kb | Distal (>10kb) Multiome | 382 |
Genomic view of the CASC15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.