This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for CAPZB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPZB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPZB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:19,209,669–19,210,758 | 275.2 kb | Distal (>10kb) Multiome | 990 | |
| chr1:19,251,426–19,252,084 | 233.9 kb | Distal (>10kb) Multiome | 930 | |
| chr1:19,311,493–19,312,976 | 173.3 kb | Distal (>10kb) Multiome | 868 | |
| chr1:19,338,257–19,338,718 | 147.0 kb | Distal (>10kb) Multiome | 426 | |
| chr1:19,484,474–19,486,386 | 161 bp | At TSS Multiome | 809 | |
| chr1:19,487,777–19,487,956 | 2.2 kb | Proximal (<10kb) | 133 | |
| chr1:19,596,392–19,597,600 | 111.4 kb | Distal (>10kb) Multiome | 888 | |
| chr1:19,640,074–19,641,053 | 155.0 kb | Distal (>10kb) Multiome HiCAR | 418 | |
| chr1:19,643,702–19,645,210 | 158.7 kb | Distal (>10kb) Multiome HiCAR | 427 | |
| chr1:19,653,578–19,654,269 | 168.4 kb | Distal (>10kb) Multiome HiCAR | 321 | |
| chr1:19,659,723–19,660,209 | 174.5 kb | Distal (>10kb) Multiome HiCAR | 316 | |
| chr1:19,704,357–19,704,828 | 219.1 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the CAPZB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.