The protein encoded by this gene is a member of the F-actin capping protein alpha subunit family. It is the alpha subunit of the barbed-end actin binding protein Cap Z. By capping the barbed end of actin filaments, Cap Z regulates the growth of the actin filaments at the barbed end. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAPZA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPZA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPZA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:116,671,633–116,673,220 | 190.4 kb | Distal (>10kb) Multiome | 926 | |
| chr7:116,861,960–116,863,478 | 36 bp | At TSS Multiome | 893 | |
| chr7:116,876,604–116,877,522 | 14.4 kb | Distal (>10kb) Multiome | 450 | |
| chr7:116,952,833–116,954,651 | 91.2 kb | Distal (>10kb) Multiome | 944 | |
| chr7:117,074,085–117,075,019 | 212.0 kb | Distal (>10kb) Multiome | 146 | |
| chr7:117,118,679–117,119,151 | 256.3 kb | Distal (>10kb) Multiome | 153 |
Genomic view of the CAPZA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.