The protein encoded by this gene may regulate the transport of mRNA. It may play a role in the differentiation of erythroblasts. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for CAPRIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPRIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPRIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:29,316,453–29,317,293 | 1438.0 kb | Distal (>10kb) Multiome HiCAR | 132 | |
| chr12:29,380,457–29,381,649 | 1373.7 kb | Distal (>10kb) Multiome HiCAR | 752 | |
| chr12:30,694,499–30,697,224 | 59.0 kb | Distal (>10kb) Multiome | 899 | |
| chr12:30,753,361–30,755,548 | 107 bp | At TSS Multiome | 947 | |
| chr12:30,794,833–30,797,324 | 40.5 kb | Distal (>10kb) Multiome HiCAR | 731 | |
| chr12:30,822,368–30,823,621 | 67.9 kb | Distal (>10kb) Multiome | 254 | |
| chr12:30,851,150–30,851,742 | 96.3 kb | Distal (>10kb) Multiome | 149 | |
| chr12:30,925,849–30,927,135 | 171.6 kb | Distal (>10kb) Multiome | 280 |
Genomic view of the CAPRIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.