Enables several functions, including ATP binding activity; molecular condensate scaffold activity; and signaling adaptor activity. Involved in membraneless organelle assembly; positive regulation of stress granule assembly; and regulation of gene expression. Located in cell leading edge and cytosol. Is active in intracellular membraneless organelle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for CAPRIN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPRIN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPRIN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:33,773,812–33,775,173 | 277.2 kb | Distal (>10kb) Multiome | 606 | |
| chr11:33,802,236–33,803,023 | 249.0 kb | Distal (>10kb) Multiome | 464 | |
| chr11:33,829,198–33,829,839 | 222.2 kb | Distal (>10kb) Multiome | 203 | |
| chr11:33,868,762–33,870,240 | 182.1 kb | Distal (>10kb) Multiome | 416 | |
| chr11:34,051,095–34,052,918 | 86 bp | At TSS Multiome | 940 | |
| chr11:34,053,201–34,053,607 | 1.5 kb | Proximal (<10kb) | 416 | |
| chr11:34,104,945–34,106,393 | 53.9 kb | Distal (>10kb) Multiome | 1046 | |
| chr11:34,174,182–34,174,889 | 122.8 kb | Distal (>10kb) Multiome | 634 | |
| chr11:34,236,421–34,237,093 | 185.1 kb | Distal (>10kb) Multiome | 194 | |
| chr11:34,262,742–34,263,988 | 211.8 kb | Distal (>10kb) Multiome | 426 | |
| chr11:34,302,438–34,303,315 | 251.2 kb | Distal (>10kb) Multiome | 271 | |
| chr11:34,309,995–34,310,608 | 258.6 kb | Distal (>10kb) Multiome | 187 |
Genomic view of the CAPRIN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.