Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAPN7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAPN7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAPN7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:14,947,039–14,949,016 | 257.8 kb | Distal (>10kb) Multiome | 992 | |
| chr3:15,064,860–15,065,480 | 140.9 kb | Distal (>10kb) Multiome | 832 | |
| chr3:15,098,771–15,099,764 | 107.1 kb | Distal (>10kb) Multiome | 1059 | |
| chr3:15,118,530–15,119,129 | 87.4 kb | Distal (>10kb) Multiome HiCAR | 281 | |
| chr3:15,305,253–15,306,068 | 99.4 kb | Distal (>10kb) Multiome | 367 | |
| chr3:15,331,772–15,333,155 | 126.4 kb | Distal (>10kb) Multiome | 642 | |
| chr3:15,356,271–15,357,033 | 150.4 kb | Distal (>10kb) Multiome | 98 | |
| chr3:15,377,980–15,378,549 | 172.1 kb | Distal (>10kb) Multiome HiCAR | 575 | |
| chr3:15,427,190–15,427,854 | 221.3 kb | Distal (>10kb) Multiome HiCAR | 758 |
Genomic view of the CAPN7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.