This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2018]
Transcription factors with Perturb-seq knockdown data for CANX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CANX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CANX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:179,530,398–179,530,934 | 168.3 kb | Distal (>10kb) Multiome | 322 | |
| chr5:179,549,624–179,551,424 | 148.1 kb | Distal (>10kb) Multiome | 799 | |
| chr5:179,559,012–179,560,188 | 139.3 kb | Distal (>10kb) Multiome | 624 | |
| chr5:179,622,406–179,625,135 | 76.2 kb | Distal (>10kb) Multiome | 1217 | |
| chr5:179,678,118–179,679,585 | 20.3 kb | Distal (>10kb) Multiome | 1007 | |
| chr5:179,698,113–179,699,498 | 168 bp | At TSS Multiome | 1062 | |
| chr5:179,732,076–179,733,697 | 33.8 kb | Distal (>10kb) Multiome | 820 | |
| chr5:179,795,059–179,796,988 | 97.3 kb | Distal (>10kb) Multiome | 778 | |
| chr5:179,805,642–179,807,610 | 108.0 kb | Distal (>10kb) Multiome | 747 | |
| chr5:179,818,809–179,822,095 | 121.9 kb | Distal (>10kb) Multiome | 1243 | |
| chr5:179,858,283–179,859,465 | 160.0 kb | Distal (>10kb) Multiome | 923 | |
| chr5:179,907,372–179,908,268 | 209.0 kb | Distal (>10kb) Multiome | 528 |
Genomic view of the CANX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.