The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]
Transcription factors with Perturb-seq knockdown data for CAMKK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMKK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMKK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:121,016,022–121,016,705 | 280.2 kb | Distal (>10kb) Multiome | 674 | |
| chr12:121,026,128–121,026,637 | 270.3 kb | Distal (>10kb) Multiome | 253 | |
| chr12:121,209,800–121,210,863 | 86.6 kb | Distal (>10kb) Multiome | 894 | |
| chr12:121,230,137–121,230,781 | 66.2 kb | Distal (>10kb) Multiome | 326 | |
| chr12:121,280,329–121,281,482 | 15.9 kb | Distal (>10kb) Multiome HiCAR | 112 | |
| chr12:121,295,441–121,297,879 | 169 bp | At TSS Multiome | 801 | |
| chr12:121,351,979–121,352,906 | 55.8 kb | Distal (>10kb) Multiome | 928 | |
| chr12:121,399,561–121,400,983 | 103.3 kb | Distal (>10kb) Multiome | 923 | |
| chr12:121,443,293–121,443,776 | 146.8 kb | Distal (>10kb) Multiome | 302 | |
| chr12:121,466,702–121,468,225 | 170.7 kb | Distal (>10kb) Multiome | 643 | |
| chr12:121,536,039–121,536,480 | 239.6 kb | Distal (>10kb) Multiome | 262 | |
| chr12:121,576,794–121,577,632 | 280.4 kb | Distal (>10kb) Multiome | 171 | |
| chr12:121,580,160–121,581,909 | 283.7 kb | Distal (>10kb) Multiome | 629 | |
| chr12:121,582,525–121,583,038 | 286.1 kb | Distal (>10kb) Multiome | 309 |
Genomic view of the CAMKK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.