This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CAMK2N2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMK2N2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMK2N2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:184,017,103–184,018,456 | 243.7 kb | Distal (>10kb) Multiome | 878 | |
| chr3:184,134,086–184,134,568 | 127.4 kb | Distal (>10kb) Multiome | 732 | |
| chr3:184,134,801–184,135,887 | 126.1 kb | Distal (>10kb) Multiome | 941 | |
| chr3:184,154,967–184,155,880 | 106.2 kb | Distal (>10kb) Multiome | 580 | |
| chr3:184,174,432–184,175,524 | 86.8 kb | Distal (>10kb) Multiome | 765 | |
| chr3:184,176,129–184,177,706 | 84.9 kb | Distal (>10kb) Multiome | 480 | |
| chr3:184,185,411–184,187,065 | 75.6 kb | Distal (>10kb) Multiome | 878 | |
| chr3:184,229,229–184,229,859 | 32.0 kb | Distal (>10kb) Multiome | 409 | |
| chr3:184,241,140–184,242,189 | 19.8 kb | Distal (>10kb) Multiome | 700 | |
| chr3:184,248,652–184,250,567 | 11.9 kb | Distal (>10kb) Multiome | 1061 | |
| chr3:184,255,398–184,255,628 | 5.9 kb | Proximal (<10kb) | 22 | |
| chr3:184,259,723–184,260,497 | 1.6 kb | Proximal (<10kb) Multiome | 318 | |
| chr3:184,260,815–184,262,571 | 141 bp | At TSS Multiome | 511 | |
| chr3:184,298,591–184,299,718 | 37.6 kb | Distal (>10kb) Multiome | 768 | |
| chr3:184,314,169–184,315,514 | 53.0 kb | Distal (>10kb) Multiome | 761 | |
| chr3:184,335,265–184,337,276 | 74.4 kb | Distal (>10kb) Multiome | 796 | |
| chr3:184,338,471–184,338,964 | 77.2 kb | Distal (>10kb) Multiome | 203 | |
| chr3:184,361,172–184,363,709 | 100.1 kb | Distal (>10kb) Multiome | 1034 | |
| chr3:184,379,849–184,380,935 | 118.6 kb | Distal (>10kb) Multiome | 242 | |
| chr3:184,513,458–184,514,228 | 252.3 kb | Distal (>10kb) Multiome | 391 | |
| chr3:184,525,317–184,526,423 | 264.4 kb | Distal (>10kb) Multiome | 281 | |
| chr3:184,561,059–184,562,613 | 300.1 kb | Distal (>10kb) Multiome | 671 |
Genomic view of the CAMK2N2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.