Predicted to enable calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Predicted to be involved in long-term memory and positive regulation of inflammatory response. Predicted to be located in neuronal cell body and synapse. Implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Biomarker of hepatocellular carcinoma; oral squamous cell carcinoma; papillary thyroid carcinoma; and prostate cancer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CAMK2N1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CAMK2N1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CAMK2N1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:20,152,028–20,152,628 | 333.8 kb | Distal (>10kb) Multiome HiCAR | 449 | |
| chr1:20,185,802–20,186,675 | 300.1 kb | Distal (>10kb) Multiome | 444 | |
| chr1:20,213,009–20,213,518 | 273.1 kb | Distal (>10kb) Multiome HiCAR | 361 | |
| chr1:20,290,425–20,291,141 | 195.4 kb | Distal (>10kb) Multiome | 203 | |
| chr1:20,342,875–20,344,326 | 142.5 kb | Distal (>10kb) Multiome | 261 | |
| chr1:20,366,975–20,367,437 | 118.9 kb | Distal (>10kb) Multiome | 164 | |
| chr1:20,483,850–20,484,757 | 1.5 kb | Proximal (<10kb) | 366 | |
| chr1:20,485,233–20,485,959 | 348 bp | At TSS Multiome | 348 | |
| chr1:20,486,131–20,487,438 | 800 bp | At TSS Multiome | 760 | |
| chr1:20,493,822–20,494,241 | 7.9 kb | Proximal (<10kb) Multiome | 430 | |
| chr1:20,507,717–20,508,432 | 21.9 kb | Distal (>10kb) Multiome | 811 | |
| chr1:20,552,019–20,553,890 | 67.4 kb | Distal (>10kb) Multiome | 518 | |
| chr1:20,625,186–20,625,881 | 139.3 kb | Distal (>10kb) Multiome | 123 | |
| chr1:20,633,024–20,634,989 | 147.6 kb | Distal (>10kb) Multiome | 759 | |
| chr1:20,661,099–20,662,130 | 175.4 kb | Distal (>10kb) Multiome | 784 | |
| chr1:20,696,319–20,697,384 | 210.7 kb | Distal (>10kb) Multiome | 727 | |
| chr1:20,717,384–20,718,370 | 231.7 kb | Distal (>10kb) Multiome | 440 | |
| chr1:20,731,726–20,733,330 | 246.1 kb | Distal (>10kb) Multiome | 718 |
Genomic view of the CAMK2N1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.