The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for CACYBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACYBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACYBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:174,799,347–174,800,510 | 199.7 kb | Distal (>10kb) Multiome HiCAR | 456 | |
| chr1:174,882,897–174,883,845 | 116.0 kb | Distal (>10kb) Multiome HiCAR | 184 | |
| chr1:174,976,347–174,977,217 | 22.7 kb | Distal (>10kb) Multiome | 181 | |
| chr1:174,998,565–175,000,705 | 355 bp | At TSS Multiome | 1242 | |
| chr1:175,022,930–175,024,023 | 24.1 kb | Distal (>10kb) Multiome | 878 | |
| chr1:175,029,423–175,030,223 | 30.4 kb | Distal (>10kb) Multiome | 562 | |
| chr1:175,073,610–175,074,084 | 74.4 kb | Distal (>10kb) Multiome | 76 | |
| chr1:175,129,648–175,130,843 | 130.8 kb | Distal (>10kb) Multiome | 246 | |
| chr1:175,146,568–175,147,254 | 147.3 kb | Distal (>10kb) Multiome | 324 | |
| chr1:175,151,904–175,152,560 | 152.8 kb | Distal (>10kb) Multiome | 185 | |
| chr1:175,154,371–175,155,390 | 155.6 kb | Distal (>10kb) Multiome | 333 | |
| chr1:175,191,731–175,193,773 | 193.5 kb | Distal (>10kb) Multiome | 565 |
Genomic view of the CACYBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.