Enables protein kinase binding activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of cell population proliferation; and positive regulation of protein kinase activity. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CACUL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CACUL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CACUL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:118,594,191–118,595,168 | 160.4 kb | Distal (>10kb) Multiome | 278 | |
| chr10:118,595,650–118,596,766 | 158.7 kb | Distal (>10kb) Multiome | 367 | |
| chr10:118,754,096–118,755,807 | 178 bp | At TSS Multiome | 975 | |
| chr10:118,759,576–118,760,773 | 5.4 kb | Proximal (<10kb) Multiome | 78 | |
| chr10:119,022,769–119,023,594 | 268.2 kb | Distal (>10kb) Multiome | 196 | |
| chr10:119,028,784–119,030,985 | 274.5 kb | Distal (>10kb) Multiome | 776 |
Genomic view of the CACUL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.