Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C5orf15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C5orf15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C5orf15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:133,686,961–133,687,622 | 281.2 kb | Distal (>10kb) Multiome | 66 | |
| chr5:133,786,502–133,787,082 | 181.9 kb | Distal (>10kb) Multiome | 59 | |
| chr5:133,968,103–133,968,907 | 27 bp | At TSS Multiome | 861 | |
| chr5:134,004,027–134,006,483 | 36.2 kb | Distal (>10kb) Multiome | 948 | |
| chr5:134,039,553–134,040,013 | 71.1 kb | Distal (>10kb) Multiome | 576 | |
| chr5:134,070,573–134,071,963 | 102.6 kb | Distal (>10kb) Multiome | 666 | |
| chr5:134,099,891–134,100,749 | 131.5 kb | Distal (>10kb) Multiome | 227 | |
| chr5:134,101,617–134,102,291 | 133.5 kb | Distal (>10kb) Multiome | 334 | |
| chr5:134,113,043–134,116,112 | 147.1 kb | Distal (>10kb) Multiome | 637 | |
| chr5:134,140,528–134,140,995 | 172.1 kb | Distal (>10kb) Multiome | 342 | |
| chr5:134,176,142–134,177,562 | 208.4 kb | Distal (>10kb) Multiome | 952 | |
| chr5:134,184,086–134,184,650 | 215.8 kb | Distal (>10kb) Multiome | 289 | |
| chr5:134,225,248–134,227,248 | 257.6 kb | Distal (>10kb) Multiome | 1043 |
Genomic view of the C5orf15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.