Involved in oxidative phosphorylation. Located in mitochondrion. Implicated in combined oxidative phosphorylation deficiency 53. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for C2orf69. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = C2orf69 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of C2orf69, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:199,850,490–199,851,605 | 60.2 kb | Distal (>10kb) Multiome | 817 | |
| chr2:199,910,668–199,912,042 | 6 bp | At TSS Multiome | 929 | |
| chr2:199,955,094–199,956,570 | 44.3 kb | Distal (>10kb) Multiome | 1078 | |
| chr2:200,090,238–200,091,621 | 180.0 kb | Distal (>10kb) Multiome | 66 | |
| chr2:200,201,704–200,202,415 | 290.8 kb | Distal (>10kb) Multiome | 128 | |
| chr2:200,203,430–200,204,082 | 292.4 kb | Distal (>10kb) Multiome | 141 |
Genomic view of the C2orf69 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.